Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes
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منابع مشابه
Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes.
Bunyaviruses replicate in the cytoplasm of infected cells. New viral particles are formed by budding of nucleocapsids into the Golgi apparatus. We have previously shown that the IFN-induced human MxA protein inhibits bunyavirus replication by an unknown mechanism. Here we demonstrate that MxA binds to the nucleocapsid protein of La Crosse virus (LACV) and colocalizes with the viral protein in c...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2002
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.052430399